- 6 - 
Attachment III - Page 6 
General Coannents 
Clinical trials of gene therapy in life-threatening cases should be 
permitted to begin now. The government should not stand in the way 
of parents' making "reasonable choices" for the lives of their 
chi ldren . 
Horowitz 
The NIH guidelines should be extended for germline cells. Also, the 
professional composition of the Working Group should be expanded to 
include more social scientists and theologians. More attention 
should be paid to the profound ethical and psychological issues 
raised by both somatic-cell and germline gene therapy. 
Rif kin 
The Working Group should be supplemented with additional specialists 
in the fields of moecular biology, pharmacology, medical chemistry, 
and medicine. Chair — should be a scientist, preferrably a physician. 
Most decisions on individual protocols will be scientific and medical. 
Miller 
The Group needs to address: 
The potential public health impact of using new techniques with 
current technological levels, etc. — appropriate technology. 
The role of public participation in the safety and desirability of 
somatic cell gene therapy experiments — care has been shown outside. 
The oversight of non-NIH funded institutions that want this 
therapy. Should there be some public service for the private? 
Goldbe rg 
[25] 
