Attachment IV - Page 4 
Leroy Walters 
February 12, 1985 
Page Two 
Finally, the parents are very well informed of the issues and 
very much want to proceed with gene therapy. Their daughter is 
going to die. There is no reasonable alternative. Gene therapy 
may have only a small chance of success, but its risks are minimal 
compared with certain death. I do not believe the government 
should stand in the way of parents making reasonable choices. It 
goes without saying that the government is already regulating such 
choices through the Institutional Review Boards, a process which I 
strongly support in theory and on its record. 
In summary, I feel that clinical trials of gene therapy in 
diseases such as ADA deficiency should begin as soon as possible. 
Sincerely , 
Sheldon Horowitz, M.D. 
Associate Professor of Pediatrics 
Division of Immunology 
SH: lk 
[ 31 ] 
