19 
Dr. Motulsky suggested this sentence should indicate defective cells are treated 
in somatic cell therapy in the hope of inserting a properly functioning gene to 
aid the patient. He thought the document should clearly state the purpose of 
the procedure is the same as the traditional purpose of all clinical interven- 
tions, namely to benefit the patient. 
Mr. Capron suggested the technique to be used, i.e., inserting a normal gene 
into bone marrow cells and reintroducing these modified cells into the patient, 
should be contrasted to germ line therapy. In germ line therapy, an attempt is 
made to change a subject's genes with the specific aim of changing the offspring' 
genes. The working group agreed to this suggestion. 
Drs. Temin and Motulsky questioned the inclusion of the sentence stating the 
working group at present will not entertain proposals for intentional germ line 
treatments but would review and approve scmatic cell protocols. They argued that 
including such a statement would limit the working group's flexibility. They 
also pointed cut that this language suggests the working group will approve 
of 9omatic cell proposals as a matter of course. 
Dr. Anderson suggested the sentence should read: "The RAC and its working 
group will not at present entertain proposals for germ line treatments, but 
will consider for approval protocols for scrratic cell gene therapy." 
The working group agreed to this proposed language. 
Dr. Motulsky suggested the language dealing with protocols "that satisfy the 
points raised in the following document" should be deleted since it also suggests 
the working group will approve of protocols as a matter of course. The working 
group agreed. 
Dr. Temin said the word "human" should modify the phrase "scmatic cell gene 
therapy . " 
Dr. Rich suggested the portion of the subworking group document (Attachment VII) 
vfoich refers to public reports and hearings should indicate the points to 
consider are consistent with these reports and discussions. 
Dr. Anderson added that the points to consider document has been widely circu- 
lated for public discussion; he suggested the low number of comments indicates 
some level of support for the position adopted by the working group. 
Mr. Capron suggested the language referring to public hearings should be modified 
to read: "Concurring with this judgment, the RAC and its working group are 
prepared to consider for approval somatic cell therapy protocols." 
Dr. Childress suggested the word "assurance" be substituted for the word "reassur- 
ance." Dr. Temin suggested the word "investigations" be substituted for the 
word "intervention." 
[104] 
