20 
Ms. Areen suggested language for the sentence dealing with undesired consequences 
as follows: 
"The two primary undesired consequences are in intentional : (1) vertical 
transmission of genetic changes from an individual to his or her offspring, 
or (2) horizontal transmission of viral infection to other persons with 
whom the individual comes in contact." 
Dr. Temin said he found the language referring to germ line therapies to be 
very strong and too closely coupled to inmediate scrmtic cell applications. 
Dr. Mot ul sky agreed with Dr. Temin; he felt this language should not be so 
strong since germ line applications at this time are hypothetical. Scrratic 
cell applications would probably have some bearing on germ line applications, 
but this bearing is not direct and guaranteed. 
Dr. McCarthy suggested the working group could simply indicate it will exercise 
vigilance over the application of data generated by somatic ceil gene therapy 
protocols and not offer any statenent on germ line applications. The document 
might indicate the working group will work with other bodies bo generate a 
public assessTent of the appropriateness of germ line applications. 
Dr. Gottesman suggested the points to consider document might simply state 
that scientific deveicpments in this, and other related fields may affect the 
development of technologies for germ line modifications. 
Dr. Walters suggested the working group delete any reference to eugenics pro- 
grams. Dr. Anderson said use of germ line therapy in eugenics programs is the 
biggest social issue associated with hurran gene therapy. He thought the docu- 
ment should refer to this potential application. Dr. Rich said the statement 
prepared by Dr. Walters (Attachment VIII) begins bo approach this issue. 
Mr. Capron suggested the working group might attempt to discuss the issues 
involved in germ line therapy; if the working group cannot address these issues. 
Congress may act to provide a forum for discussion. 
Dr. Rich reiterated his suggestion that the working group develop a nontechnical 
document addressing technical and social issues. He said he would be willing 
to write a first draft of a position paper on the social issues associated 
with human gene therapy. 
Dr. Anderson offered bo provide a bechnical briefing to the working group at 
the next meeting of the working group. 
Mr. Mitchell said the RAC would next convene on May 3, 1985. He said the 
points to consider document prepared by the Working Group on Hurran Gene Therapy 
will he presented to the RAC at that meeting. 
Dr. Walters suggested the next meeting of the Working Group on Human Gene 
Therapy would be held in late spring or sumer of 1985. Dr. Walters adjourned 
the meeting of the Working Group on Human Gene Therapy at 4:05 p.m. 
[ 105 ] 
