Tab A - Page 7 
into the environment of any microorgani sm containing recombinant ONA cannot be 
initiated without submission of relevant information on the experiment to NIH, 
the publication of the proposal in the Federal P.eqlster for 30 days of comment, 
review by the NIH Recombinant ONA Advisory Committee (RAC) and a specific 
approval by NIH based on Its finding that the experiment will present "no 
significant risk to health or the environment." 
On September 17, 1982, Ors. Steven Lindow and Nickolas Panopoulos of the 
University of California, Berkeley, requested permission from NIH to field test 
Pseudomonas syrlnqae pv. syringae and Erwinia herbicol a carrying j_n vitro 
generated deletions of all or part of the genes involved In Ice nucleation for 
purposes of biological control of frost damage to plants. (E) 
On September 22, 1982, NIH gave notice of this request in the Federal 
Register announcing that it would be considered at the October 25, 1982, RAC 
meeting and that "Interested parties are invited to submit comments." (F) 
In addition to publication in the Federal Register , this notice was sent 
to more than 3,000 Interested persons who, at their request, are on a mailing 
list to receive Federal Register notices related to the NIH Guidelines for 
Research Involving Recombinant ONA Molecules. Furthermore, all RAC members. 
Including the liaison members to the RAC from other Federal agencies, and 
others, were sent, prior to the October 25, 1982, RAC meeting, a copy of the 
Federal Register notice and a copy of the Llndow-Panopoulos , 98 page, 
September 17, 1982, submission. Copies were also made available to all 
members of the public present at the October 25, 1982, RAC meeting. 
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