Tab A - Page 8 
No public comments on the Lindow-Panopoulos submission were received In 
response to the September 22, 1982, Federal Register notice. The Lindow- 
Panopoulos submission was reviewed at the October 25, 1982, RAC meeting 
attended by 16 RAC members, 23 representatives of Federal agencies other than 
NIH, and 43 others. The RAC recommended approval of the Lindow-Panopoulos 
proposal by a vote of seven In favor, five opposed, and two abstentions. (G) 
In the Federal Register of January 10, 1983, NIH announced that "because 
of concerns raised at the RAC meeting, approval of the proposed field tests is 
being withheld. The investigators nay bring this or a modified proposal back 
for consideration at a future RAC meeting." (H) 
On March 8, 1983, Drs. Lindow and Panopoulos submitted a revised proposal 
(I). This proposal was modified compared to the September 17, 1982, proposal, 
in response to environmental concerns raised at the October 25, 1982, RAC 
meeting. Among other changes it provided for testing in only one small field 
rather than at the six locations proposed in the original request, it stated 
that only chromosomal antibiotic resistance markers would be used to monitor 
the strains, and It addressed the concern regarding the possible effect of the 
field test on rainfal 1 . 
On March 4, 1983, NIH gave notice of this request in the Federal Register 
announcing that It would be considered at the April 11, 1983, RAC meeting and 
that "Interested parties are invited to submit comments." (J) 
In addition to this notice being distributed to all those who receive the 
Federal Register , It was again sent by the NIH Office of Recombinant DNA 
5 
[ 202 ] 
