GENEPvJ-COR 
Tab C - Page 11 
May 10, 1985 
NIH Office of Recombinant DNA Activities (ORDA) 
Building 31 
Room 3B10 
National Institutes of Health 
Bethesda, MD 20205 
RE: Federal Register Notice of April 15, 1985 
Genencor, Inc., an industrial enzyme producer, would like to take 
this opportunity to comment on the above referenced Federal 
Register notice requesting comment on the "Environmental 
Assessment and Finding of No Significant Impact" dated January 
21, 1985 "concerning the application to the National Institutes 
of Health (NIH), under the NIH Guidelines for Research Involving 
Recombinant DNA Molecules, of Drs. Steven Lindow and Nickolas 
Panopolous of the University of California, Berkeley, to field 
test ice-nucleation-minus bacteria prepared by recombinant DNA 
techniques for purposes of biological control of frost damage to 
plants . " 
We have reviewed the Environmental Impact Statement (EIS) and 
find it to be thorough and well done and we agree with the 
finding by NIH of no significant impact. Further, from our 
understanding of the programatic EIS and the varied nature of 
recombinant organisms and environments in which they may be 
released, we feel that the assessment of their environmental 
impact can best be determined on a case-by-case basis through 
site specific environmental impact statements rather than a 
programatic EIS. 
We thank you for this opportunity to comment. 
Sincerely, 
(]JUj L t 
Alice K. Jameson 
Manager of Regulatory Affairs 
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