On July 28, 1978, NIH published for public comment in the Federal Register 
(totalling 136 pages) proposed revised Guidelines together with "Decision of the 
Director, NIH, to Issue Revised Guidelines for Recombinant DNA Research," and 
an Environmental Impact Assessment Following analysis of the public comments 
received, NIH published in the Federal Register on December 22, 1978, revised 
Guidelines for Recombinant DNA Research," and an Enviromental Impact 
Assessment. The Guidelines have been revised many times since December 1978. 
Copies of all revisions are available from the NIH Office of Recombinant DNA 
Activities, Building 31, Room 3B10, NIH, Bethesda, Maryland 20205. The most 
recent complete republication of the Guidelines was in the Federal Register of 
November 23, 1984. 
The NIH Recombinant DNA Advisory Committee (RAC) consists of 25 voting 
members, appointed by the Secretary of the Department of Health and Human 
Services, including laymen and scientists of many different disciplines. The RAC 
also has non-voting liaison representatives from the following other Federal 
agencies: 
Department of Agriculture 
Department of Commerce 
Department of Defense 
Department of Health and Human Services 
—Office of the Assistant Secretary for Health 
—National Institutes of Health 
—Centers for Disease Control 
—National Institute for Occupational Safety and Health 
—Food and Drug Administration 
Environmental Assessment 
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