CONTENTS 
Memorandum on transition to revised Guidelines 1 
Letter to heads of institutions receiving NIH support 5 
Signs designating PI laboratories [See explanatory note, p. 5] 7 
NIH Director's Decision to publish revised Guidelines 9 
NIH Guidelines for Research Involving Recombinant DNA Molecules 
(January 29, 1980) 15 
[The following documents are essentially in chronological order.] 
Federal Register announcement (January 15, 1979) of actions to 
be considered at RAC meeting 43 
Minutes of RAC meeting, February 15-16, 1979 47 
Federal Register notice (April 11, 1979) promulgating actions 80 
Recombinant DNA Research; Proposed Plan For a Program to 
Assess Risks 88 
Federal Register announcement (April 13, 1979) of actions to 
be considered at RAC meeting 92 
Minutes of RAC meeting. May 21-23, 1979 96 
Federal Register notice (July 20, 1979) promulgating actions 127 
Minutes of meeting of the Federal Interagency Advisory Committee 
on Recombinant DNA Research, July 17, 1979 132 
Federal Register announcement (July 31, 1979) of actions to be 
considered at RAC meeting 144 
Federal Register announcement (August 3, 1979) of actions to be 
considered at RAC meeting 147 
Minutes of RAC meeting, September 6-7, 1979 150 
Proposed revised Guidelines of November 30, 1979 195 
Decision/environmental impact assessment (November 30, 1979) 220 
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