FEBRUARY 15-16 - MINUTES OF MEETING 
11 
The vote on Dr. Gottesman's proposal to amend Dr. Baltimore's 
motion was 12 in favor, 7 opposed, with 1 abstention. 
The RAC then voted on the amended motion as follows: 
"Experiments involving complete genomes of eukaryote 
viruses will require P3 + HV1 or P2 + HV2 contain- 
ment levels." 
This motion passed by a vote of 17 to 1 with 2 abstentions. 
Executive Secretary's Note : Since this is a major change in 
the proposed action as it appeared in the Federal Register on 
January 15, 1979, additional opportunity for public comment 
is appropriate. Accordingly, this proposed action will be 
published for an additional 30-day cement period and will 
be reconsidered by the RAC at its next meeting. 
3. Applicability to Wild Type Neurospora crassa . 
Mr. Thornton moved that Neurospora crassa wild type not be 
considered HV1 for equivalence. The motion passed 18 to 0 
with 2 abstentions. (See reference to this in Executive 
Secretary's Note at end of section IV-C of the Minutes). 
V. REMARKS OF MRS. FRANCINE SIMRING 
Mrs. Francine Simring, representing the Coalition for Responsible Genetic 
Research, commended DHEW for expanding the membership of the RAC. Mrs. 
Simring suggested that the following topics be considered by the RAC: 
use of language intelligible to all, applications of the research, pro- 
gram of risk assessment, interim regulation of industry, procedures for 
approving exceptions and exemptions, written disclosure of affiliations, 
professional conflict of interest, and distribution of material to the 
RAC. She said that decreases in containment levels should be held in 
abeyance until additional risk assessment data are available. 
VI. SACCHAROMYCES CEREVISIAE HV2 SYSTEMS. 
The RAC reviewed an application (603) submitted by Dr. David Botstein 
et al. for certification of sterile yeast hosts (SHY strains of Saccharo- 
myces cerevisiae ) as HV2 containment systems when used with a variety of 
composite vectors capable of replication and/or integration in yeast. 
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