May 21-23 - MINUTES OF MEETING 
10 
Director, NIH, give further consideration to this matter. The RAC 
initially voted in favor of Dr. Redford's amendment by a vote of 11 in 
favor, 4 opposed, and 5 abstentions. The RAC then reconsidered its 
action by voting on whether to substitute Dr. Redford's motion for 
Dr. KrimsKy's motion. The vote was 8 in favor, 9 opposed, with 4 
abstentions. 
The RAC then voted 9 in favor, 6 opposed, with 6 abstentions on Dr. Krimsky' 
original motion that the RAC supports mandatory compliance by nort-NIH 
funded institutions. 
VIII. LARGE-SCALE PROJECTS 
h . appointment of Working Group 
Dr. Barkley introduced a brief discussion on large-scale 
experiments. It was agreed that a group should examine 
physical containment requirements for large-scale 
experiments and that a document should be prepared. 
Dr. Kutter moved that a working group on large-scale 
experiments should be appointed, consisting of members 
of the RAC and other consultants. The RAC voted 19 
to 0 with no abstentions in favor of the motion. 
Later in the meeting. Dr. Setlow appointed a Working 
Group on Large-Scale Experiments consisting of 
Drs. Walters (Chairman), Krimsky, Young, and Barkley 
(NIH staff). 
B. Interim Procedures 
At its February 15-16, 1979 meeting, the RAC adopted an 
interim procedure for the handling of requests for large- 
seal^ experiments involving reccmbinants that are 
rigorously characterized and free of harmful sequences. 
That procedure expired at the May meeting. Dr. Baltimore 
moved that the previous procedure be extended. 
Dr. Goldstein proposed that the comment period for all 
members of the RAC be extended from 1 week to 3 weeks. 
It was agreed that all submissions should also be sent 
to Dr. Barkley for review. 
Tne RAC tnen passed by a vote of 16 in favor, 3 opposed, 
witn 1 abstention on extension of the interim procedure 
as follows: 
Requests for large-scale experiments 
(e.g., more than 10 liters of culture) 
involving reccmb inant CNAs that are 
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