May 21-23 - MINUTES OF MEETING 
16 
Dr. Rowe urged such a working group to explore new mechanisms for admin- 
istering recombinant DMA research, such as certifying local IBCs to make 
decisions. Dr. Ahmed suggested that non-RAC members should have an 
opportunity to cement. Dr. Jonathan King again raised concerns about 
the possibility of autoimune disease, and the transfer of recombinant 
molecules from laboratory strains to non- laboratory strains. 
The RAC then passed Dr. Williams' motion by a vote of 17 to 0, with 3 
abstentions. 
Later in the afternoon. Dr. Baltimore again introduced the subject 
with a variation that all recombinant DNA experiments involvina E. coli 
K-12 host-vector systems should be permitted under PI conditions, rather 
than being totally exenpt from the Guidelines. He said that his pro- 
posal would involve registration with the local IBC with the forwarding 
of a registration document to ORDA. Dr. Novick said that this is a 
proposal that should be considered at the next meeting. Dr. Kutter 
said that this proposal should be considered to be advice to the 
Working Group. Dr. Homick stated that autoimmune disease arising from 
recombinant DNA research is a oonjectural problem, and that no abnormalities 
were uncovered with unusually large amounts of vaccines produced at 
Ft. Detrick over a 20-year period. The RAC then voted 18 to 3, with 
1 abstention, in favor of recommending Dr. Baltimore's proposal for 
consideration by the Working Group. 
Later in the meeting, Dr. Setlow appointed Drs. Williams (chairman), 
Gottesnan, Novick, and Proctor to this Working Group. 
XII. TRANSFER OF CLONED DNA SE3GMEUTS TO EUKARYOTIC ORGANISMS 
Based on the reccrrmendation of the RAC at its February 15-16, 1979 
meeting, the NTH previously approved the return of DNA seamen ts to a 
higher eukaryotic host of origin as stated in the Federal Register 
on April 11, 1979: 
"II I-C-6 . Return of DNA Segments to a Higher 
Eukaryotic~Host of Origin .' DNA from a higher 
eukaryote (Host D) may oe inserted into a 
lambdoid phage vector or into a vector from a 
certified EX 2 host-vector system and propaaated 
in EL coli K-12 under the appropriate containment 
conditions [see Section III-A-1] . Subsequently, 
this recombinant DNA may be returned to Host D 
and propagated under conditions of physical con- 
tainment comparable to PI and appropriate to the 
organism under study [2A]." 
cm] 
