SEPTEMBER 6-7 - MINUTES OF MEETING 
15 
Following this, there was a general discussion concerning procedures for 
handling all classes of exempt experiments. Dr. Campbell then proposed 
an amendment to the motion that would 1) strike the words "can be handled 
at Pi," 2) add the amendment proposed by Mr. Thornton, i.e., adding 
"subject to the prohibitions of I-D-l through I-D-6" after the word 
"Guidelines," and 3) add the following wording: 
"Investigators carrying out such experiments 
must submit a registration document that 
contains (a) a description of the source(s) 
of ENA, (b) nature of the inserted DNA 
sequences and (c) the hosts and vectors to 
be used. This registration document must 
be dated and signed by the investigator and 
filed only with the local IBC, with no 
requirement for review by the IBC prior to 
initiation of experiments. Pi containment 
shall be used for all experments in these 
categories." 
Dr. Zaitlin expressed concern about the level of training of the individuals 
involved. It was felt that training is built into the requirement for 
use of Pi containment. Dr. Walters expressed concern that Dr. Campbell's 
proposal would create a new category of partial exemptions. The RAC 
then voted 11 to 0, with 3 abstentions, to accept Dr. Campbell's amendment. 
Dr. Zaitlin expressed concern about not requiring prior approval by the 
IBC. There have been questions of interpretation as to whether certain 
experiments are exempt. Under this proposal, the experiments would be 
already underway. Dr. Zaitlin moved to add the words "Prior to the 
initiation of experiments" before the wording in the third section of 
Dr. Campbell's motion. Dr. Gottesman stated that if one is concerned 
about a product produced in K-12, then one should not vote for this 
motion. She said these amendments indicate that the RAC is not sufficiently 
sure about the K-12 system that it is willing to exempt it. The RAC 
then voted 14 to 0, with 1 abstention, in favor of Dr. Zaitlin' s 
amendment. 
Dr. Novick then proposed an amendment to substitute the wording "are 
exempted from some of the procedures specified in the Guidelines" for 
the words "are exempted from the Guidelines." The RAC voted not to 
accept this amendment by a vote of 2 in favor, 9 opposed, with 3 abstentions. 
The RAC then voted 10 in favor, 4 opposed, with 1 abstention on the 
amended action which is worded as follows: 
"Those recombinant DNA molecules that are 
propagated in E. coli K-12 hosts not containing 
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