SEPTEMBER 6-7 - MINUTES OF MEETING 
16 
conjugation-proficient plasmids or generalized 
transducing phages, when lambda or lambdoid 
bacteriophages or non-conjugative plasmids are 
used as vectors, are exempted from the Guidelines, 
subject to the prohibitions of I-D-l through 
I-D-6. Prior to initiation of the experiments, 
investigators wishing to carry out such exper- 
iments must submit a registration document 
that contains (a) a description of the source(s) 
of DNA, (b) nature of the inserted DNA sequences 
and (c) the hosts and vectors to be used. 
This registration document must be dated and 
signed by the investigator and filed only with 
the local IBC with no requirement for review 
by the IBC prior to initiation of experiments. 
Pi containment shall be used for all experiments 
in these categories." 
Drs. Ahmed, Goldstein, and Krimsky requested that they be recorded as 
voting opposed. 
VII. REMARKS OF DIRECTOR, NIH 
Dr. Fredrickson spoke to the RAC, thanking them for their service. He 
pointed out that a new era is beginning in which the handling of 
proprietary data will become inescapable if the fruits of recombinant DNA 
technology are to be realized. Dr. Krimsky asked Dr. Fredrickson hew 
NIH is going to respond to the RAC suggestion at the May 21-23 meeting 
recommending mandatory compliance by industry with the Guidelines. 
Dr. Fredrickson responded he had on June 8 conveyed the motion of the RAC 
to HEW Secretary Califano who was not inclined to seek new legislation at 
this time. Mr. Califano did, however, wish brought to the Federal 
Interagency Committee on Recombinant DNA Research, the question of whether 
NIH should proceed with its proposal for voluntary compliance. In a 
unanimous opinion in July the Interagency Ccmmittee suggested that NIH 
proceed with publication for public comment of the draft supplement to the 
NIH Guidelines for voluntary compliance by industry. Dr. Wright noted 
that two years ago. Dr. Fredrickson believed that NIH should not get involved 
in the business of regulation. She asked Dr. Fredrickson if the NIH 
position had changed. Dr. Fredrickson responded that the position of 
NIH had not changed. 
VIII. PROPOSED REGISTRATION OF CURRENTLY EXEMPT EXPERIMENTS 
The question of whether experiments exempt under Section I-E of the current 
Guidelines should be registered was discussed. A proposal for such registration 
had been sent to the RAC (706). Dr. Gottesman said that registration of 
experiments under Sections I-E-l and I-E-2 should not be required. Dr. Novick 
agreed. Therefore, only experiments covered under Sections I-E-3 through 
I-E-5 should be considered. Dr. Baltimore saw no reason to change the 
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