Federal Register / Vol. 44, No. 232 / Friday, November 30. 1979 / Notices 
69233 
Salmonella — all species and all serotypes. 
Shigella — all species and all serotypes. 
Sphaerophorus necrophorus. 
Staphylococcus aureus. 
Streptobacillus moniliformis. 
Streptococcus pyogenes. 
Treponema carateum. T. pallidum, and T. 
pertenue. 
Vibrio fetus, V. comma, including biotype 
El Tor, and V. parahemolyticus. 
Fungal Agents: 
Actinomycetes 1 (including Nocardia 
species and Actinomyces species and 
Arachnia propionica). 
Blastomyces dermatitidis. 
Cryptococcus neoformans. 
Paracoccidioides brasiliensis. 
3. Parasitic Agents: 
Endamoeba histolytica. 
Leishmania sp. 
Naegleria gruberi. 
Toxoplasma gondii. 
Toxocara cams. 
Trichinella spiralis. 
Trypanosoma pruzi. 
4. Viral. Rickettsial, and Chlamydial 
Agents: 
Adenoviruses — human — all types. 
Cache Valley virus. 
Coxsackie A and B viruses. 
Cytomegalo viruses. 
Echoviruses — all types. 
Encephalomyocarditis virus (EMCL 
Flanders virus. 
Hart Park virus. 
Hepatitis-associated antigen material. 
Herpes viruses — except Herpesvirus 
simiae (Monkey B vims) which is in Class 4. 
Corona viruses. 
Influenza viruses — all types except A/PR8/ 
34. which is in Class 1. 
Langat virus. 
Lymphogranuloma venereum agent 
Measles virus. 
Mumps virus. 
ParainPuenza virus — aM types except 
Parainfluenza virus 3. SF4 strain, which is In 
Class 1. 
Polioviruses — all types, wild and 
attenuated. 
Poxviruses — all types except Alastrim. 
Smallpox, Monkey pox. and Whitepox, which 
depending on experiments, are in Class 3 or 
Class 4. 
Rabies virus — all strains except Rabies 
street virus, which should be classified in 
Class 3 when inoculated into carnivores. 
Reovirusis — all types. 
Respiratory syncytial virus. 
Rhinoviruses — all types. 
Rubella virus. 
Simian viruses — all types except 
Herpesvirus simiae (Monkey B virus) and 
Marburg virus, which are in Class 4. 
Sindbis virus. 
Tensaw virus. 
Turlock virus. 
Vaccinia virus. 
Varicella virus. 
Vole rickettsia. 
Yellow fever virus. 17D vaccine strain. 
C. Class 3 Agents 
1. Bacterial Agents: 
' Since the publication of the classification tn 1974 
|1). the Actinomycetes have been reclassified as 
bacterial rather than fungal agents. 
Actinobacillus mallei ’. 
Bartonella — all species. 
Brucella — all species. 
Francisella tularensis. 
Mycobacterium avium. M. bovis. M. 
tuberculosis. 
Pasteurella multocide type B ("buffalo" 
and other foreign virulent strains *). 
Pseudomonas pseudomallei \ 
Yersenia pestis. 
2. Fungal Agents: 
Coccidioides immitis. 
Histoplasma capsulatum. 
Histoplasma capsulatum var. duboisii. 
3. Parasitic .Agents: Schistosoma mansonL 
4. Viral. Rickettsial, and Chlamydial 
Agents: 
Alastrim. Smallpox. Monkey pox. and 
Whitepox, when used in vitro. 
Arboviruses — all strains except those in 
Gass 2 and 4. (Arboviruses indigenous to the 
United States are in Class 3. except those 
listed in Class 2. West Nile and Semliki 
Forest viruses may be classified up or down, 
depending on the conditions of use and 
geographical location of the laboratory.) 
Dengue virus, when used for transmission 
or animal inoculation experiments. 
Lymphocytic choriomeningitis virus (LCM). 
Psittacosis-Ornithosis-Trachoma group of 
agents. 
Rabies street virus, when used in 
inoculations of carnivores (See Class 2). 
Rickettsia — all species except Vole 
rickettsia when used for transmission or 
animal inoculation experiments. 
Vesicular stomatitis virus 
Yellow fever virus — wild, when used in 
vitro- 
D. Class 4 Agents 
1. Bacterial Agents: None. 
2. Fungal Agents: None. 
3. Parasitic Agents: None 
4. Viral. Rickettsial, and Chlamydial 
Agents: 
Alastrim. Smallpox. Monkey pox. and 
Whitepox, when used for transmission or 
animal inoculation experiments. 
Hemorrhagic fever agents, including 
Crimean hemorrhagic fever (Congo), funin, 
and Machupo viruses, and others as yet 
undefined. 
Herpesvirus simiae (Monkey B vims). 
Lassa virus. 
Marburg'virus. 
Tick-borne encephalitis virus complex, 
including Russian spring-summer 
encephalitis, Kyasanur forest disease, Omsk 
hemorrhagic fever, and Central European 
encephalitis viruses. 
Venezuelan equine encephalitis virus, 
epidemic strains, when used for transmission 
or animal inoculation experiments. 
Yellow fever virus — wild, when used for 
transmission or animal inoculation 
experiments. 
II. Classification of Oncogenic Viruses on the 
Basis of Potential Hazard (2) 
A. Low Risk Oncogenic Viruses 
Rous Sarcoma. 
SV— 40. 
’ USD A permit also required for import or 
interstate transport. 
CELO. 
Ad7-SV40. 
Polyoma. 
Bovine papilloma. 
Rat mammary tumor 
Avian Leukosis. 
Murine Leukemia. 
Murine Sarcoma. 
Mouse mammary tumor. 
Rat Leukemia. 
Hamster Leukemia. 
Bovine Leukemia. 
Dog Sarcoma. 
Mason-Pfizer Monkey Virus. 
Marek's. 
Guinea Pig Herpes. 
Luck6 (Frog). 
Adenovirus. 
Shope Fibroma. 
Shope Papilloma. 
B. Moderate-Risk Oncogenic Viruses 
Ad2-SV40. 
FeLV. 
HV Saimiri. 
EBV. 
SSV-1. 
GaLV. 
HV ateles. 
Yaba. 
FeSV. 
III. Animal Pathogens (3) 
A. Animal disease organisms which are 
forbidden entry into the United States by 
Law (CDC Class 5 agent) 
1. Foot and mouth disease virus. 
B. Animal disease organisms and vectors 
which are forbidden entry into the United 
States by USDA Policy (CDC Class 5 Agents) 
African horse sickness virus. 
African swine fever virus. 
Besnoitia besnoiti. 
Borna disease virus. 
Bovine infectious petechyial fever. 
Camel pox virus. 
Ephemeral fever virus. 
Fowl plague virus. 
Goat pox virus. 
Hog cholera virus. 
Louping ill virus. 
Lumpy skin disease virus. 
Nairobi sheep disease virus. 
Newcastle disease virus (Asiatic strains). 
Mycoplasma mycoides (contagious bovine 
pleuropneumonia). 
Mycoplasma agalactia (contagious 
agalactia of sheep). 
Rickettsia ruminatium (heart water). 
Rift valley fever virus. 
Rinderpest virus. 
Sheep pox virus. 
Swine vesicular disease virus. 
Teschen disease virus. 
Trypanosoma vivax (Nagana). 
Trypanosoma evansi. 
Theileria parva (East Coast fever). 
Theileria annulata. 
Theileria lawrencei. 
Theileria bovis. 
Theileria hirci. 
Vesicular exanthema virus. 
Wesselsbron disease virus. 
Zyonema farciminosum (pseudofarcy). 
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