Federal Register / Vol. 44, No. 232 / Friday, November 30, 1979 / Notices 
69251 
Officer, Bureau of Oceans and 
International Environmental and Scientific 
Affairs. Department of State. 2201 C Street, 
N.W., Washington, D.C. 20520, 202-632- 
4826. 
Department of Transportation 
Mr. Douglas A. Crockett, Department of 
Transportation, Transpoint Building. Room 
6405, 2100 Second Street. S.W.. 
Washington, D.C. 20590. 202-426-2075. 
U.S. Arms Control and Disarmament Agency 
Robert Mikulak. Ph.D., Physical Science 
Officer, Multilateral Affairs/ Advanced 
Technology, U.S. Arms Control and 
Disarmament Agency. 21st Street and 
Virginia Ave., N.W.. Washington. D C. 
20451. 202-632-3424. 
Veterans Administration 
|ane S. Schultz. Ph D.. Chief. Program Review 
Division. Veterans Administration Central 
Office. 810 Vermont Avenue, N.W., Room 
755, Washington, D C. 20420. 202-389-5065. 
8-374-5678 (Mich.). 
Additional Announcement of the 
Director, NIH 
Section IV— E— 1— b— (3)— (d) of the 
Guidelines gives responsibility to the 
Director, NIH, for "authorizing, under 
procedures specified by the RAC. large- 
scale experiments (i.e., involving more 
than 10 liters of culture) for recombinant 
DNAs that are rigorously characterized 
and free of harmful sequences." 
On October 5, 1979. the Director. NIH. 
on the recommendation of the 
Recombinant DNA Advisory Committee, 
approved a request from Lilly Research 
Laboratories for the lowering of 
containment and large-scale culture of 
EKl host-vector systems carrying the 
chemically synthesized insulin A chain 
and B chain separately. The request was 
approved with the understanding that 
Lilly Research Laboratories have agreed 
to permit an observer, designated by 
NIH, to visit the facilities if NIH should 
choose to inspect the site. 
The principal investigator is Dr. 
Lawrence E. Day. The work is to be 
done, as stipulated in the submission by 
Lilly Research Laboratories, in a "P2 
laboratory containing fermenters 
designed and pretested to totally 
contain the organisms until they are 
chemically or physically killed at the 
end of each fermentation ... at the 
plant facilities at 1200 South Kentucky 
Avenue, Indianapolis. Indiana, 46206." 
Dated: November 26. 1979. 
Donald S. Fredrickson, 
Director National Institutes of Health. 
(FI) Doc 79-3M42 Filed 11-29- T9. 8 45 ami 
BILLING CODE 41 10-08-M 
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