Dr. Wallace P. Rowe 
- 2 - 
April 30, 1979 
over fifteen years ago, and by Dr. Grodsky and his colleagues in rabbits. Although 
this is a possibility, it would take repeated infections with the insulin-producing 
E.coli over a lengthy period of time and I suppose that the body might then be 
so hyper-immune that (he recurrent infections themselves might not occur unless 
different strains of E.coli were used with each re-infection and each carrying 
an insulin-producing gene. 
Thus in summary, it is comforting to notice that the NIH is very aware of the 
potential hazards of developing bacterial strains producing mammalian proteins 
such as insulin, but in this case the desire for insulin production to meet the 
world's needs so far outweighs the hypothetical hazards as speculated on above, 
that I hope the considerations of any governing body not be held up too long because 
of these minimal potential risks. 
Sincerely yours, 
GFC/lhl 
, M.D. 
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