ROCHE INSTITUTE OF MOLECULAR BIOLOGY 
Nutley, New Jersey 07110 
July 31, 1979 
Dr. Donald Frederlckson 
Director 
NATIONAL INSTITUTES OF HEALTH 
9000 Rockville Pike 
Bethesda, MD 20205 
Dear Dr. Frederickson, 
I would like to add my support to the sentiments of many other 
molecular biologists and biochemists to exempt recombinant DNA experi- 
ments carried out in the _E. coll K12 host from the NIH Guidelines. It 
seems clear now that such experiments pose no risk, and therefore, do 
not justify the considerable amount of red tape involved in compliance. 
Please give your personal consideration to the adoption of the K12- 
exemption proposal of Wallace Rowe and Allan Campbell. 
L. Patrick Gage, Ph.D. 
Department of Cell Biology 
