Dr. Donald Fredrickson 
Page 2. 
October 16, 1979 
It seems to me that these observations ought strongly to be taken into 
account in your decision regarding the classification of experiments carried 
out in K12 strain of coli , which, even without the burden of foreign 
DNA, is not a good competitor in nature. 
If there is anything further I can do in support of the proposal, please 
feel free to call upon me. 
Sincerely yours^ 
David Botstein 
Professor of Genetics 
BD:po 
cc: Dr. Wallace P. Rowe, N.I.H. 
Dr. William Gartland, ORDA, N.I.H. 
Dr. Daniel Liberman, Biohazards Assessment Officer, M.I.T 
[ 355 ] 
