Continued - Dr. Donald Frednickson 
Page 2 
necessary to reduce paper work of investigators and local Biosafety 
Caimittees. If this is not done in the near future, the amount of 
work required will become so great that the important matters brought 
before these caimittees will not receive the attention deserved. I 
would modify the RAC decision slightly, however, by suggesting that 
even those recombinant experiments exempt from the Guidelines should be 
registered with the local Biosafety Conmittee but should not require 
specific oonmittee action. 
I hope you act favorably on this re carmen dat ion of the NIH Recombination 
Advisory Conmittee. 
With warm personal regards, I remain, 
Yours very truly , 
/csm 
Harold S. Ginsberg, M.D. 
Chairman 
[ 357 ] 
