MINUTES OF MEETING - December 6-7 
12 
impression that Dr. Callis described a set procedure for shipment 
of materials from Plum Island and not an evaluation of the hazard. 
Dr. Callis said he had described a set procedure for shipment 
of a viable agent. He said that non-infectious material can be 
shipped according to NIH shipping procedures. 
Dr. Walters moved the following substitute motion: 
"That the entire matter of the appropriate physical and 
biological containment levels for Stages II and III to 
be performed at Genentech be referred to the working group 
that will report back to the RAC." 
Dr. Baltimore said that no purpose would be served by relegating 
the issue to a working group. Dr. Brill suggested that the RAC 
might require that the transported materials be opened under P3 
conditions. Once the canister is opened, PI conditions would be 
used. The Walters motion was denied by a vote of five in favor, 
twelve opposed, and one abstention. The RAC then voted on the 
Campbell amendment to substitute PI + EK1 for P3 + EK2 or P2 + EK2. 
The amendment was accepted by a vote of nine in favor, seven 
opposed, with two abstentions. Dr. Setlow then called for a 
vote on Part 3 of the motion as amended by Dr. Campbell's 
amendment. 
"That experiments with the Foot and Mouth Disease clones 
at Genentech be carried out at PI + EK1 containment." 
The motion was accepted by a vote of nine in favor, seven opposed, 
with two abstentions. Dr. Goldstein requested that his vote be 
recorded as opposed. 
Dr. Gottesman then presented Part 4 of her motion. It was agreed 
that this portion does not have to be dealt with under the present 
situation. 
Dr. Set lew appointed a working group composed of Drs. Baltimore, 
Young, Campbell, and Gottesman. Dr. Krimsky at a later time in the 
meeting said he would like to make available to this working group, 
documents reporting on an outbreak of Foot and Mouth Disease on Plum 
Island in 1978 (Attachment IV). 
V. PROPOSED EXEMPTION OF EXPERIMENTS IN TISSUE CULTURE 
The RAC began consideration of tab 789. Dr. Talbot said that 
this is a major action which has not appeared in the Federal 
Register for public comment in connection with this meeting; 
therefore, final action by the RAC cannot occur at this meet- 
ing. Dr. Rowe questioned this since it v/as part of the major 
actions published for comment in the Federal Register two 
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