MINUTES OF MEETING - December 6-7 
21 
focus on real hazards and that their effectiveness is short 
circuited to the extent that they are overloaded. Dr. Krimsky 
said the amount of extra effort on the part of the local IBC 
would be minimal. He said it is a matter of filing a list with 
the IBC chairman. The proposal doesn't stipulate that the IBC 
evaluate or review any of the experiments, nor does it say 
anything about the IBC having to produce the information except 
for an OREA request. Dr. Krimsky said that in the event of an 
outbreak, epidemiologists may find such a registry useful. 
Dr. Young said that he opposes this motion. He is opposed to 
adding one more level of paper work which does not provide any 
safety function. Dr. Walters said that the proposal introduces 
an unnecessary disproportion between the rules that apply to 
recombinant DNA research and the rules that apply to other 
types of research. Dr. Ahmed moved approval of the proposal. 
The RAC disapproved this motion by a vote of five in favor, ten 
opposed, with four abstentions. 
XII. AGENDA 
Dr. Setlcw suggested that the RAC continue on into the next day's 
schedule. Dr. Ahmed asked whether it is fair to advance items 
so much on the agenda. Dr. Pauker of NIOSH pointed out that 
there are non-voting liaison representatives that handle many 
other matters for their agencies. These representatives may 
wish to attend the discussion of some specific items and they 
will determine from the published agenda when issues of importance 
to them are going to be discussed. Ms. King said that the RAC 
is a public meeting and one of the criteria of a public meeting 
is a published agenda. She said the RAC should not make changes 
in the agenda without notification. Mr. Thornton suggested that 
future agendas should indicate that the agenda may be changed. 
Drs. Young and Mason suggested future agendas contain a statement 
that the time of consideration of specific items is only an 
approximation. Dr. Setlow said she sensed the sentiment to be 
for adjournment. The RAC then adjourned for the day. 
XIII. PROPOSED AMENDMENT OF SECTION III-B-2, III-C-5, III-C-6, AND 
III-C-7-a OF THE GUIDELINES 
Dr. Gottesman presented the submission of Dr. David Hogness of 
Stanford University (tabs 766, 774/4). Dr. Gottesman said that 
the language of Sections III-B-2, III-C-5, and III-C-6 of the 
Guidelines requires that a lambdoid phage vector or an approved 
EK2 vector be used for certain experiments involving "return of 
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