MINUTES OF MEETING - December 6-7 
29 
of Medicine, Michael Reese Hospital and Medical Center, 
Chicago, Illinois, and Dr. Philip Y. Paterson who is pro- 
fessor of microbiology and immunology at Northwest University 
Medical and Dental Schools, Chicago, Illinois. 
Dr. Krause summarized the report of the meeting (Attach- 
ment III). Hie meeting was concluded with an agreement that 
the following initiatives will be undertaken: (1) All of the 
risk assessment data on E. coli K-12 including the evidence 
concerning possible colonization will be drawn together as 
rapidly as possible and made available for review by all 
interested parties. (2) A small group of individuals will 
be brought together to discuss possible risks that might be 
associated with E. coli K-12 producing biologically active 
peptides, including hormones. (3) A second small group of 
individuals will be convened to discuss the possible risks 
arising from immunological events that might be initiated by 
E. coli K-12 that are producing eukaryotic polypeptides, 
"Including hormones. Dr. Krause said that NIAID would like 
to move as rapidly as possible to convene these groups. 
Dr. Krause said NIAID will hold the meeting at a time when 
the largest numl^er of knowledgeable people can attend. An 
invitation will be extended to all RAC members. 
Dr. Goldstein asked that two documents dealing with the biology 
of E. coli be made available to the RAC. These are articles 
by Dr. Stanley Falkcw and Dr. Roy Curtiss. Dr. Goldstein 
requested that Dr. Falkow be invited to attend the next RAC 
meeting. Dr. Goldstein asked whether the question of rheumatic 
fever had been raised at that NIAID meeting. Dr. Krause said 
that one possibility studied for many years is that rheumatic 
fever is an aberrant immunological reaction to Streptococcal 
infection. He said it is true that there are Streptococcal 
antigens cross reactive with mammalian tissue but that there is 
no evidence that antibodies to these are involved in patho- 
genesis. In addition, very few infected individuals develop 
rheumatic fever. 
B. Preposed amendment of Section I-D of the Guidelines 
Dr. Gottesman began this presentation (tab 774/10). She said 
the proposal suggests that experiments prohibited by Sections 
I-D-l, I-D-2, I-D- 3 and I-D- 5 and experiments involving "wild 
type" host-vector systems be excepted from the prohibition. 
[ 422 ] 
