MINUTES OF MEETING - December 6-7 
34 
a different approach might be required with a large spill. 
Dr. Novick questioned whether an architectural barrier is 
required. Dr. Johnson of Eli Lilly summarized some key points 
in his detailed comments (tab 806) on the large-scale proposal. 
He said there should be a Pl-LS containment level. Architectural 
curbs are not necessary. He enumerated several additional 
specific suggestions. 
Dr. Canpbell said that once a project is approved on a pilot 
scale, scale-up to a larger facility should not require detailed 
reconsideration by the RAC. The RAC should indicate in the 
original approval whether the properties of the organism would 
give cause for concern should a large amount be worked with. 
Dr. Myers of NIOSH said that his agency will evaluate the draft 
standards. He noted that he has several questions on the Labora- 
tory Procedures section. Dr. Krimsky suggested that procedures 
to monitor worker-health should be specified for large-scale 
experiments. Dr. Wright said that in the United Kingdom there 
is industry and trade union representation on OlAG. 
Dr. Walters requested that the RAC authorize ORTA and the working 
group actively to solicit comments from public interest groups, 
industry, Federal agencies, organizations of workers, GMAG, and 
other organizations concerning the draft standards. Mr. Thornton 
so moved and the RAC accepted this motion by a vote of fifteen 
in favor, none opposed, with no abstentions. Based on the comments 
received, the draft standard will be revised and considered again 
at the March 1980 meeting. 
XVII. CLOSED SESSION 
The RAC went into closed session to consider proposals from 
comercial concerns for scale-up of recombinant DNA experiments. 
XVIII. FURITJRE MEETING CATES 
The RAC selected the following dates for future meetings: 
March 6-7, 1980 
June 5-6, 1980 
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