UNIVERSITY OF CALIFORNIA, LOS ANGELES 
BERKELEY • DAVIS • IRVINE • LOS ANGELES • RIVERSIDE • SAN DIECO • SAN FRANCISCO 
SANTA BARBARA • SANTA CRUZ 
MOLECULAR BIOLOGY INSTITUTE 
LOS ANGELES, CALIFORNIA 90024 
December 5, 1979 
Dr. Donald S. Fredrickson 
Director, National Institutes 
of Health 
Bethesda, Maryland 20014 
RE: Recombinant DNA Guidelines and Federal Registrar, Friday, November 30, 1979 
Dear Dr. Fredrickson, 
I wish to support the proposed changes in the NIH guidelines as described in 
the Federal Registrar of Friday, November 30, 1979. These reductions in 
containment requirements are entirely consistent with developments in the 
past two years which have shown the safety of E. coli K12 carrying eukaryotic 
DNA sequences. In addition, the reduction in containment and administration 
should allow for more rapid and meaningful advances. 
Sincerely yours. 
George C. Fareed 
Associate Professor 
GCF/cm 
[ 436 ] 
