ST.JVDE CHILDREN'S RESEARCH HOSPITAL 
332 North Lauderdale. PO Box 318, 
Memphis, Tennessee 38101 
(901) 525-8381 
Danny Thomas, Founder 
11 December 1979 
Dr. Donald S. Fredrickson 
Director 
National Institutes of Health 
Bethesda, Maryland 20205 
Dear Dr. Fredrickson: 
I am writing in support of the latest revision of the NIH Recombinant 
DNA Guidelines, published in the Federal Register, November 30, 1979. 
In my opinion, the Advisory Committee has acted responsibly and the 
proposed changes will expedite the acquisition of new knowledge 
without subjecting the public to risk. 
In particular, I would stress the practical importance of section 
III-O, "Classification of Experiments Using the E. coli K-12 Host- 
Vector Systems". As in the past, the great majority of experiments 
will be done using this system, under safe conditions, and it will 
eliminate a great deal of useless paperwork if these cases can be regu- 
lated at the local level. 
Sincerely, 
David W. Kingsbury, M.D. 
DWK/hmh 
