UNIVERSITY OF CALIFORNIA, LOS ANGELES 
BERKELEY • DAVIS • IRVINE • LOS ANCELES • RIVERSIDE • SAN DIECO • SAN FRANCISCO 
SANTA BARBARA • SANTA CRUZ 
and Immunology 
School of Medicine 
The Center for the Health Sciences 
Los Angeles, California 90024 
December 14, 1979 
Dr. Donald S. Fredrickson 
Director, National Institutes of Health 
Bethesda, Maryland 20014 
RE: Recombinant DNA Guidelines and Federal Registrar, 
Friday, November 30, 1979 
Dear Dr. Fredrickson, 
I strongly support the proposed changes in the NIH guidelines 
as described in the Federal Fegistrar of Friday, November 30, 1979. 
These reductions in containment requirements are entirely consistent 
with developments in the past two years which have shown the safety 
of l. col i K12 carrying eukaryotic DNA sequences. In addition, the 
reduction in containment and administration should allow for more 
rapid and meaningful advances in research. 
Sincerely 
ncer 
Randolph Wal 1 , Ph,D. 
Professor of Microbiology 
and Immunology 
RW/jk 
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