UNIVERSITY OF SOUTHERN CALIFORNIA 
SCHOOL OF MEDICINE 
2011 ZONAL AVENUE 
LOS ANGELES. CALIFORNIA 90033 
DEPARTMENT OF MICROBIOLOGY 
TELEPHONE: (213) 22S-2142 
December 14, 1979 
Dr. D. Fredrickson 
Director NIH 
Bethesda, MD 20205 
Dear Dr. Fredrickson: 
I would like to express my strong support for the proposed change in 
the guidelines for research involving recombinant DNA mol ecul es . The 
change in question entails a down-grading of containment requirements 
for experiments using E. ooli K-12. Experience with this host-vector 
system has shown it to be safe under the conditions proposed. 
I believe safety to be a very important consideration in all recombinant 
DNA experiments, but I also feel that the guidelines presently in force 
still contain restrictions which appear unnecessary safeguards. There- 
fore, I am in favor of the proposed changes published in the federal 
register of November 13, 1979. 
With kind regards. 
Sincerely ypurs. 
Peter K. Vogt, Ph.D. 
Professor of Microbiology 
PKV:rl z 
[ 496 ] 
