Yale University 
New Haven, Connecticut 06510 
SCHOOL OF MEDICINE 
333 Cedar Street 
Department of Human Genetics 
December 17, 1979 
Dr. Donald Frederickson 
Director, 
National Institutes of Health 
Bethesda, MD 20205 
Dear Donald: 
I am writing this letter with regard to the Part VII, Federal 
Register, National Institutes of Health, Recombinant DNA 
Advisory Committee meeting, Sec. III-O. I would like to express 
my personal opinion and my impression that it is 
the opinion of the overwhelming majority of my scientific 
colleagues that the change in the Guidelines as listed in 
Sec. III-O is highly desirable and appropriate. I personally 
feel that it would be even more appropriate and without 
any real risk of hazard at all and with considerable benefit 
for science, were these experiments to be totally deregulated, 
but in the absence of this change, the changes in Section III- 
-0 would represent a considerable move for the better and 
expedite all sorts of important biological research. 
Sinfprpl \7 
Sherman M. Weissman,M.D. 
Professor of Human Genetics 
Medicine and Molecular 
Biophysics and Biochemistry 
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