CALIFORNIA INSTITUTE OF TECHNOLOGY 
PASADENA. CALIFORNIA 01125 
December 17, 1979 
Dr. Donald S. Frederickson 
Director, National Institutes of Health 
Bethesda, Maryland 20014 
RE: Recombinant DNA Guidelines and Federal Registrar. 
Friday, November 30, 1979 
Dear Dr. Frederickson: 
I wish to support the proposed changes in the NIH guidelines 
as described in the Federal Registrar of Friday, November 30, 1979. 
These reductions in containment requirements are entirely consistent 
with developments in the past two years which have shown the safety 
of E. coli K12 carrying eucaryotic DNA sequences. In addition, the 
reduction in containment and administration should allow for more 
rapid and meaningful advances. 
Sincerely yours 
NIH Postdoctoral Fellow 
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