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fyifo'icebte'i 04605 
MEDICAL CENTER 
DEPARTMENT OF MICROBIOLOGY 
55 Lake Avenue North 
December 17, 1979 
Telephone: (617) 856-2292 
Dr. D. Fredrickson, Director 
National Institutes of Health 
Bethesda, MD 20205 
Dear Dr. Fredrickson: 
I would like to strongly support the proposed changes in the NIH guidelines 
on recombinant DNA research; in particular, those which would classify most 
experiments using the E. coli K-12 host vector systems as Pl-EK-1. These 
changes represent a reasonable compromise between the growing evidence that 
recombinant DNA presents essentially no danger and the lag in the public 
understanding of this evidence. 
Sincerely yours, 
Lydia Vi I la-Komarott , pn.L). 
Assistant Professor 
LVKrjtg 
[520] 
An Equal Opportunity Employer 
