MEMORIAL SLOAN-KETTERING GANGER CENTER 
Donald S. Frederickson 
Director, National Institutes of Health 
Bethesda, MD 20205 
Dear Dr. Frederickson: 
I strongly urge the adoption of the proposed Recombinant 
DNA Guidelines set forth in the Federal Register, Vol. 44, 
No. 232, Nov. 30, 1979. The E. coli K-12/P1 recommendation 
embodies a realistic assessment of several years' 
experience with this system as well as direct tests of its 
safety. Adoption of the Revised Guidelines will greatly 
facilitate work in this field. 
1275 YORK AVENUE, NEW YORK. NEW YORK 10021 
December 18, 1979 
Yours truly 
Eileen Friedman, Ph.D. 
Associate, Sloan-Kettering Institute 
EF: jw 
[529] 
MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES 
SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH 
SLOAN-KETTERING DIVISION, GRADUATE SCHOOL OF MEDICAL SCIENCES, CORNELL UNIVERSITY 
