CALIFORNIA INSTITUTE OF TECHNOLOGY 
PASADENA, CALIFORN IA ©1125 
DIVISION OF CHEMISTRY AND CHEMICAL ENGINEERING 
THE CHEMICAL LABORATORIES 
December 18, 1979 
Dr. Donald S. Frederickson 
Director, National Institutes of Health 
Bethesda, Maryland 20014 
Dear Dr. Frederickson: 
I support the revised guidelines for recombinant DNA research 
as they appeared in the Federal Register for November 30, 1979. 
There are 3 key points. (1) Experience and medical microbiology 
have shown E. coli K12 to be a safe vector for recombinant DNA 
experiments. (2) Institute Biohazards Committees can easily 
monitor local activities and control for potentially dangerous 
experiments. (3) The new rules will free investigators from much 
unnecessary administrative duties and allow more rapid progress. 
Sincerely yours 
Judith L. Campbell 
JLC/mca 
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