UNIVERSITY OF CALIFORNIA, LOS ANGELES 
BERKELEY • DAVIS • IRVINE • LOS ANCELES • RIVERSIDE • SAN DIEGO • SAN FRANCISCO 
SANTA BARBARA • SANTA CRUZ 
MOLECULAR BIOLOGY INSTITUTE 
LOS ANCELES, CALIFORNIA 90024 
December 18, 1979 
Dr. Donald S. Fredrickson 
Director, National Institutes of Health 
Bethesda, Maryland 20205 
Re: Recombinant DNA Guidelines and Federal 
Registrar, Friday, November 30, 1979 
Dear Dr. Fredrickson: 
I am writing this letter to support the proposed change in 
the NIH guidelines for November 30, 1979. I feel that the proposed 
major changes in the containment requirements for experiments 
involving £. col i host-vector system are adequate based on the 
experimental results obtained in the past. I support the change 
as proposed. 
Sincerely, 
Harumi Kasamatsu 
Associate Professor of 
Molecular Biology 
HK:ad 
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