New Haven, Connecticut 06510 
SCHOOL OF MEDICINE 
Department of Epidemiology 
and Public Health 
60 College Street 
December 19, 1979 
Dr. Donald S. Frederickson, Director 
National Institutes of Health 
Bethesda , MD 20205 
Dear Dr. Frederickson: 
As a member of Yale University's Institutional Biohazards Committee, I 
am writing to express strong support for the content and wording of the pro- 
posed revised recombinant DNA guidelines published in the Federal Register of 
November 30 1979. 
In particular, I endorse the new section 1 1 1 -0 , concerning experiments 
using E-coli K 12 as host, and urge adoption of this section. 
Yours sincerely. 
James C. Niederman, M.D. 
Professor of Epidemiology 
and Medicine 
JCN:ald 
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