UNIVERSITY OF CALIFORNIA, LOS ANGELES 
UCLA 
BERKELEY • DAVIS • IRVINE • LOS ANCELES • RIVERSIDE • SAN DIECO • SAN FRANCISCO 
SANTA BARBARA • SANTA CRUZ 
DEPARTMENT OF BIOLOGY 
LOS ANGELES, CALIFORNIA 90024 
Decentoer 20, 1979 
Dr. Donald S. Fredrickson 
Director 
National Institutes of Health 
Bethesda, Maryland 20014 
Dear Dr. Fredrickson, 
I am writing to express my support for the proposed changes 
in the NIH Recombinant DNA Guidelines as described in the Federal 
Register of Friday, Noverrber 30, 1979. These reductions in 
containment requirements are entirely consistent with developments 
in the past two years which have shown the safety of Escherichia 
coli K12 carrying eukaryotic DNA sequences. Moreover , the 
reduction in containment and administration should allow for more 
rapid and meaningful advances at less expense . 
Sincerely 
Michael Grunstein 
Associate Professor 
Molecular Biology Institute 
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