Donald S. Fredrickson, Director 
National Institutes of Health 
Bethesda, Md. 20014 
Dear Dr. Fredrickson: 
This letter is to support the E. coli K12/P1 Recommendation (made by the 
RAC on 6-7 September 1979) as outlined in your Decision Document/Environmental 
Impact Assessment published in Federal Register 44^(232) : 69234-69246 , of 30 
November 1979. 
After careful consideration of the data, I strongly and without reser- 
vation support the passage of the E. coli K12/P1 Recommendation. It is clear 
that the use of E:. coli K12 strains in recombinant DNA experiments provides 
no hazard either to people or to our environment. Passage of the Recommendation 
would allow recombinant DNA research, now limited by the present restrictions 
on E. coli vectors, to proceed forward. This will without doubt accelerate 
the advances in medical treatment made possible with this methodology. To 
deny the passage of the Recommendation would continue to limit progress in 
experimental medicine in this country and thus be detrimental to the interests 
of the American people. 
Again, I give full support for the immediate passage of the E^. coli 
K12/P1 Recommendation. 
Yours sincerely, 
)v\ A. r*"s. 
Marcelle R. Morrison, Ph.D. 
Assistant Professor of Neurology 
MRM/ls 
[ 553 ] 
5323 HARRY HINES BLVO. 
DALLAS, TEXAS 75235 
(214) 688-3535 
