Stanford University. Stanford. California 94e*)B 
Department of Biological Sciences 
CHARLES YANOFSKY 
Morris Herzsteln Professor 
December 20, 1979 
of Biology 
Dr. Donald S. Fredrickson 
Director, National Institutes of Health 
Bethesda, Maryland 20205 
Dear Dr. Fredrickson: 
I have examined the Proposed Guidelines for Research Involving 
Recombinant DNA Molecules in the Friday, November 30, 1979 
Federal Register . Having served on the Stanford IBC and having 
had scientists in my laboratory engaged in recombinant DNA 
research, I have considerable familiarity with the Guidelines 
and their application. I consider the measures in the new 
proposed Guidelines to be substantially improved over those 
in the previous version. In particular, section III-O should 
facilitate research involving recombinant DNAs without in any 
way increasing the potential risks from such research. I 
enthusiastically endorse the new version of the Guidelines, 
Sincerely yours. 
Charles Yanofsky 
CY/an 
[ 564 ] 
