The Johns Hopkins Oncology Center 
Biochemical Virology Laboratory 
301/955-8900 
December 21, 1979 
Dr. Donald Fredrickson, Director 
NIH 
Bethesda, MD 20205 
Dear Dr. Fredrickson: 
I am writing this letter in support of the proposed downgrading of containment 
for recombinant DNA experiments utilizing the E coli K12 host-vector systems as 
outlined in the Federal Register, November 30, 1979. I support this action after 
having followed the debate concerning the safety of these experiments over the 
last several years. I am personally convinced, as a physician and scientist, 
that the proposed downgrading is indicated. I also feel that this downgrading 
is essential to allow the rapid progress in the production of therapeutic agents, 
as well as increase our knowledge of diseases such as cancer. 
Assistant Professor, Oncology & Medicine 
The Johns Hopkins University School of Medicine 
mas 
r570] 
601 North Broadway, Baltimore, Maryland 21205 
