Dr. Donald Fredrickson 
- 2 - 
December 21, 1979 
(8) In the discussion on conferring pathogenicity on E . co 1 i K-12 (p. 69239), 
the very important concept of the "inherent early warn i ng" [T.I.B.S.: k_ 
(1979) p. N 1 90 ] is missing, C. 
(9) I recommend not including section VI "Voluntary Compliance", since: 
(a) there are no scientific reasons for it unless some "early warning" 
should materialize and be proven to arise from the recombinant DNA 
technique, 
(b) this section may mislead legislative bodies and lead to unnecessary 
and wasteful legislative attempts, 
(c) this section will result in further increase in bureaucracy and 
unnecessary waste of funds, time and effort. 
(10) The name of Dr. Brill is misspelled on p. 69249. 
(11) I believe that the design of Tables I-IV published in Gene: 5_ (1979) 
pp. 187-190 is much easier to follow than Tables III and IV in the Proposed 
Guidelines (pp. 69220 and 69223). I would be glad to help with preparing 
corresponding updated Tables for the final version of the Guidelines. &cU>SAie A . 
I hope these specific comments will be of help to you. 
With best wishes for a Merry Christmas and a successful New Year. 
Sincerely yours, 
Waclaw Szybalski 
Professor of Oncology 
WS:ms 
Enel . 
[ 581 ] 
