THE UNIVERSITY OF CHICAGO 
DEPARTMENT OF BIOCHEMISTRY 
920 EAST 5 8 T H STREET 
CHICAGO • ILLINOIS 60637 
December 21, 1979 
Dr. Donald Fredrickson 
Director of the N.I.H. 
National Institutes of Health 
Bethesda, Maryland 20205 
Dear Dr. Fredrickson: 
I am not a current user of recombinant DNA technology but I am 
an expert in the Field. I do hope that you will relax the current NIH 
guidelines. Tlie risk of this research has never been established and the 
guidelines should never have been so strict. The result is to slow down 
research, e.g. by forcing investigators to use sick E. coli strains. A 
mountain of paperwork is created, wasting time and money. 
Sincerely yours 
Nicholas R. Cozzarelli 
Professor 
NRCraj 
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