THE WISTAR INSTITUTE 
THIRTY-SIXTH STREET AT SPRUCE 
PHILADELPHIA, PA. 19104 
HILARY KOPROWSKI, M.D. 
Phone: (215) 243-3700 
DIRECTOR 
CABLE ADDRESS: WISTARINST 
January 2, 1980 
Dr. Donald S. Fredrickson, Director 
National Institutes of Health 
Office of the Director 
Building 1, Room 124 
Bethesda, Maryland 20205 
Dear Dr. Fredrickson, 
I would like to comment on the proposed amendments of the 
guidelines for Recombinant DNA (Federal Register Vol. 44^ 232, 
November 30, 1979). 
With relationship to the III-O paragraph (page 69218), I think 
that this measure was long overdue and should be approved. 
In addition. Section I-E-2 is unclear to me. Does this also refer 
to eukaryotic virus inserts? 
I hope these comments are of some use. 
Sincerely yours 
Robert Weinmann 
Associate Professor 
RW : emy 
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