PREFACE 
This is the twelfth in a series constituting a "public record" of activities in regard to the 
National Institutes of Health (NIH) Guidelines for recombinant DNA research. 
The first eleven volumes cover events from February 1975 through April 1987. This 
twelfth volume is the Human Gene Therapy Preclinical Data Document submitted to the 
Human Gene Therapy Subcommittee of the Recombinant DNA Advisory Committee on 
April 24, 1987, by Drs. Anderson, Blaese, Nienhuis, and O’Reilly. 
Volumes 1 through 5 in this series and the Environmental Impact Statement may be 
purchased from the Superintendent of Documents, U.S. Government Printing Office 
(GPO), Washington, DC 20402 or GPO bookstores in selected cities throughout the 
United States. They may also be viewed in some 600 public libraries of the GPO 
depository system. The GPO stock numbers are: Volume 1, 017-004-00398-6; Volume 
2, 017-040-00422-2; Volume 2 Supplement (Environmental Impact Statement), 017-040- 
00413-3; Volume 3, 017-040-00429-0; Volume 3 Appendices, 017-040-0043-3; Volume 4, 
01 7-040-00443-5; Volume 4 Appendices 01 7-040-00422-7; and Volume 5, 01 7-040-00470- 
2. Volumes 6 through 1 1 are available from the Office of Recombinant DNA Activities, 
Building 31, Room 4B11, National Institutes of Health, Bethesda, MD 20892 USA. 
Recombinant DNA Research, Volume 12 
