and location 
6. Publicity may be excessive because of public scrutiny required (see 
special section re: loss of privacy, which may become unavoidable) 
7. Procedure may not work and child would remain ill 
RISKS AND HAZARDS 
The following is a list of foreseeable risks related to the procedure. 
They range from low probability speculation to highly significant 
complications, any of which, should it occur, may not be correctable or 
reversibl e. 
1. Complications of the procedure - anesthesia, infection, anaphalaxis on 
infusion, possible embolic phenomema from aggregates of cells, local reaction 
at injection site with possible damage to organs previously unaffected by the 
disease 
2. Severe infection, possibly leading to death prior to engraftment 
3. Failure to engraft 
4. Failure of significant number of engrafted cells to be treated or 
successfully express ADA 
5. Failure to cure disease despite good engraftment 
6. Autoimmune disease is theoretical possibility 
7. Cancer (either as a result of insertional mutagenesis or of prolonged 
survival with the original defect) 
8. Other disease occurring as a result of change in DNA, possibly 
interrupting another important gene which needs both copies to function 
9. Unknown disease caused by activation of a DNA sequence which should remain 
off 
10. Unknown disease resulting from viral activation 
11. Unknown toxicity from contaminants which either cannot be detected or were 
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Recombinant DNA Research, Volume 12 
