Table 2 
Gene transfer and expression In vitro using retroviral vectors 
derived frost Mo-MuLV. 
Vector Genes Promoter Cell type Cells Ref 
Infected assayed 
PlPAL 
human HPRT 
Mo-MuLV LTR a rat HPRT cells 
20BF 
Hiller et al.. 1983 
PL PL 
human HPRT 
LNSV 
PNAS 80. A709 
Flbrobl asts 
5 8 
2 5 
<X Q 
0 c 
— 
01 4# 
« T) U K 
— 4» 4* O O 
> C M L < C 
b « T3 Z « C 4» O 
c o c >» O ^ — 
■W- C u « *f* — 
4* 6 TJQV*' 
M U 4 If a ^ >> o o 
U « TJ - I O w «— «— 
CW CO L V- U I 
« 4 « 3 ** 
3 — C— «-*<UCC 4 < 
0 M « C t- « E 
4* 4» v* — ^ O' Of 
L C I* 4 
•» - T) z: 
w u • a • 
- — 
L VQ< IU ZZ 
a c < a. oo f-o.2 
3 .30 
— ►“06 
O* ■* 
4 0 U 0 4*’*- — 
MLV-NEOI 
b 
neo 
SV40 early 
murine bone 
CFU-GM 
Joyner et al .. 1983 
region 
marrow 
Nature 305. 556. 
pZIP-AOA 
human AOA c /neo 
Mo-MuLV LTR 
murine flbro- 
NIH 3T3 
Valerio et al .. 1984 
bl asts 
Gere 34. 163. 
PZPAH 
human PAH neo 
Mo-MuLV LTR 
murine fibro- 
NIH 3T3 
Ledley et al.. 1986 
blast murine 
PNAS 83. 409. 
hepatoma cells 
heoal -a 
PZIPOHFR 
OHFR* e / human AOA 
Mo-MuLV LTR 
murine lymphoid 
70Z pre 
Williams et al.. 1986 
-ADA 
cells 
B cells 
PNAS 83. 2566. 
thymoma 
cel 1 s 
pZIPHFR 
OHFR*/human AOA 
Mo-MuLV LTR' 
human AOA" B 
GM2471 
. 
-SVAOA 
SV40 eariy 
cells 
region 
POOL 
human GC f /neo 
Mo-MuLV LTR 
human Gaucher 
GM126C 
Choudary et al.. 1986 
HP10 
flbrobl asts 
Mol . Biol . Med. 3. 293 
pN2 
neo 
Mo-MuLV LTR 
human bone 
CFU-GM 
Hock i Miller. 1986 
marrm 
BFU-E 
Nature 320. 275. 
CFU-MIx 
pN2 
neo 
Mo-MuLV LTR 
murine flbro- 
NIH 3T3 
Kwok et al.. 1986 
bl asts 
PNAS 83. 4552. 
Mo-MuLV LTR 
canine flbro- 
CFZTH 
. 
bl asts 
SV40 early 
canine bone 
CFU-GM 
. 
promoter 
marrow 
SAI 
neo/ human AOA 
Mo-MuLV LTR/ 
human AOA * T 
TJF-2 
Kantof f et al . . 
SV40 early 
cells 
1986. PNAS 83. 
region 
human AOA * B 
GM 2756 
6563. 
cells 
GM 4258A 
pZIP-SV 
neo/ human AOA 
Mo-MuLV LTR 
murine bone 
CFU 
Belmont et al . . 1986 
(B1A0A 
marr»« 
Nature 3 22. 385. 
LNSAL 
neo/ human ADA 
Mo-MuLV LTR/ 
AOA human 
H0F-SFO3 
Palmer et al . . 1987 
SV40 early 
flbrobl asts 
PNAS 84. 1055. 
region 
pNZ-FAT 
neo/ human 
Mo-MuLV LTR/ 
murine flbro- 
NIH 3T3 
Garver et al . . 1987 
nj - AT 9 
SV40 early 
bl asts 
PNAS 84. 1050. 
region 
LHM S PL/ 
HPRT/human PNP h 
Mo-MgLV LTR/ 
murine flbro- 
Mclvor et al .. 1987 
LHM : PL 
MMP 1 
bl asts 
Molec. Cell Biol. 7. 
838. 
LHM s Al/ 
HPRT/human AOA 
MO-MuLV LTR/ 
murine flbro- 
LHM «■ PL 
MMP 
bl asts 
nZIP- 
human HPRT/neo 
Mo-MuLV LTR 
murine HPRT 
NIH 3T3 
Chang et al . . 1987 
NeoSV(l)/ 
cells 
HPRT 
Molec . Cell 81 ol . 7 . 
HPRT (3) 
854. 
HPRT human 
RJK984 
lymphobl asts 
oSVI t (PO) human glob In/ 
Mo-MuLV LTR 
murine erythro- 
MEL 
Cone et al . . 1 987 
neo 
leukemla cells 
Mol ec . Cel 1 Biol . 7 . 
887. 
SAX 
neo/human AOA 
Mo-MuLV LTR/ 
murine flbro- 
NIH 3T3 
McLachlln et al .. 
SV40 early 
bl asts 
CV-1 
1987 Analy. Slo- 
region 
monkey kidney 
chem. (In press) 
cells 
CV-1 
Recombinant DNA Research, Volume 12 
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