Listing of Follow-up Clinical Studies 
LAB TESTS 
TEST 
pretransplant 
frecruencv 
autoosv 
B CELL TESTS 
Serum Ig levels: 
IgG, IgA, IgM, IgE 
IgG and IgA 
subgroups 
yes 
yes 
biweekly x 5 yes 
then monthly 
every 3 months yes 
Antibody titers: 
blood group, E.coli, 
diphtheria, tetanus, 
gpvo 
yes 
monthly 
yes 
in vivo immune 
challenges : 
killed polio vaccine 
HiB, Pneumovac, 
phiX174 , KLH 
, no 
no 
no 
12 months after 
15 months after 
12 months after 
therapy 
if pt>2 years 
therapy 
RETROVIRAL TESTS 
S+L- 
virus rescue 
yes 
yes 
monthly 
monthly 
yes 
yes 
see B cell tests for 
see T cell tests for 
antibody to gp70 
altered self assay with gp70 
TISSUE SAMPLES 
thymus biopsy 
lymph node biopsy 
yes 
yes 
lyr 
lyr 
yes 
yes 
PRODUCING CELL LINES 
T cell: 
both IL-2 expanded and yes 
HTLV-1 transformed 
every 3 months 
yes 
B cell: 
EBV transformed 
yes 
every 3 months 
yes 
Banked samDles 
serum, white 
blood cells 
yes 
weekly x 6 
then monthly 
yes 
bone marrow 
examination 
yes 
at time of 
treatment 
then every 
6 months 
yes 
Recombinant DMA Research, Volume 12 
[213] 
