Summary 
Primate bone marrow cells were infected with a retroviral vector carrying 
the genes for human adenosine deaminase (h-ADA) and bacterial neaiycin 
resistence (neofy . The infected cells were infused back into the lethally 
irradiated donor animals. Several monkeys fully reconstituted and were shown 
to express the h-ADA and neo^ genes at low levels in their circulating 
hematopoietic cells for short periods of time. 
The authors thank Sheri Bernstein, Jane Selegue, Pat Turner and Teresa 
Cartagena for their excellent technical assistance; Brian Agricola, Natalie 
Antinoff, Ronald Prinm and Kathy Fliszar for the daily care of the animals? 
Dr. Joseph Pierce for assistance in caring for the animals; and Beth Russo for 
help with the manuscript. E.G. is supported by a grant from the March of Dimes 
1-1047. A.G., C.B., N.A.K., R.J.O. are supported in part by PHS grant 33050 
and CA08748 awarded by the National Cancer Institute, DHHS, as well as grants 
from the Zelda Weintraub Cancer Foundation, Robert J. Kleberg and Helen C. 
Kleberg Foundation, the Yankee-Frito Lay Challenge Foundation, Lila Ache son 
Dewitt Wallace Foundation, the Vincent Astor Chair for Clinical Research, the 
Andrew Gaffney Foundation, and the Penway Foundation. A.G. is supported in 
part by the Toys-R-Os Foundation. C.B. is a Leukemia Society of America 
Fellow. N.A.K. is supported in part by a Clinical Scholars Award from the 
Norma and Rosetta Winston Foundation. 
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Recombinant DNA Research, Volume 12 
