I. INTRODUCTION 1 
A. Concerns .. 3 
(re^ IU--Q. 
B. Characteristics Of The Safest Possible Retrovirus Vector System For Human Somatic4 
C. Risk Assessment .. 5 
D. Appropriate Models For Comparison Of Risks - .5 
II. TYPES OF POTENTIAL BIOLOGICAL PROBLEMS WITH SOMATIC GENE 
THERAPY OF HUMAN DISEASE WITH RETROVIRUS VECTORS 
A. Problems That Can Not Be Removed By Further Genetic Engineering 
B. Theoretically Possible, But Unlikely Biological Problems 
ID. SOCIAL PROBLEMS (INDIVIDUAL AND GENERAL) 
A. When Should Retrovirus Gene Therapy Be Used? 
B. Cost and Effectivenss 
C. Geneml^e^ariEffects 
IV. Summary 
..7 
...7 
...8 
12 
12 
.14 
.14 
.15 
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Recombinant DNA Research, Volume 12 
