pp. 1-38, 1986. 
130. Shimada, T. , Chen, M.-J., and Nienhuis, A.W. : A human 
dihydrofolate reductase intronless pseudogene with an 
Alu repetitive sequence: Multiple DNA insertions at a 
single chromosomal site. Gene 31:1-8, 1984. 
131. Sands, J., Macher, A., Ley, T. , and Nienhuis, A.W.: 
Disseminated infection caused by Cunninghamelia 
bertholletiae in a £ thalassemia patient receiving 
5-azacytidine . Ann. Int. Med. 102:59-63, 1985. 
132. Nienhuis, A.W. , Ley, T.J., Humphries, R.K. , Young, N.S., 
and Dover, G.: Pharmacological manipulation of fetal 
Hemoglobin synthesis in patients with severe 
thalassemia. Ann. N.Y. Acad. Sci. . 445:198-211, 1985. 
133. Anagnou, N.P., Papayannopoulou , T. , Stamatoyannopoulos , 
G. , and Nienhuis, A.W. : Structurally diverse molecular 
deletions in the /9-globin gene cluster exhibit an 
identical phenotype or interaction with the /?s-gene. 
Blood 65:1245-1251, 1985. 
134. Karlsson, S., Humphries, R.K. , Gluzman, Y. , and 
Nienhuis, A.W. : Transfer of genes into hematopoietic 
cells using recombinant DNA viruses. Proc. Natl. Acad. 
Sci. 82:158-162, 1985. 
135. Shimada, T. , and Nienhuis, A.W. : Only the promoter 
region of the constitutively expressed normal and 
amplified human dihydrofolate reductase gene is 
DNasel hypersensitive and undermethylated. J. Biol. 
Chem. 260:2468-2474, 1985. 
136. Rodgers, G. , Schechter, A., Noguchi, C., Klein, H. , 
Nienhuis, A., and Bonner, R. : Periodic microcirculatory 
flow in patients with sickle cell disease. N. Eng. J. 
Med, 311:1534-1538, 1984. 
137. Ley, T. and Nienhuis, A.: Prospects for Therapeutic 
Manipulation of Human Gene Function. In Principles 
and Techniques of Human Research and Therapeutics . 
Proceedings of the Third International Symposium. 
Futura Press, 1984. 
138. Karlsson, S. and Nienhuis, A.W. : Developmental regulation 
of human globin genes. Ann. Rev. Biochem. 54:1071-1108, 1985. 
139. Nienhuis, A.W. : Genetic mechanisms in neoplasia. 
Blood 64:949-950, 1984. 
140. Karlsson, S. and Nienhuis, A.W. : Recent advances in 
diagnosis and treatment of the hereditary globin gene 
disorders. Saudi Medical Journal , submitted 1985. 
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Recombinant DNA Research, Volume 12 
