CONTENTS 
Federal Register of August 21 , 1982, revised NIH Guidelines 1 
Federal Register of November 28, 1980, announcing actions to be 
considered at a meeting of the NIH Recanbinant DI^ Advisory 
Ocmmittee !RAC), January 8-9, 1981 23 
Minutes of the RAC meeting, January 8-9, 1981 26 
Federal Register of March 12, 1981, pronulgating actions recommended at 
the RAC meeting, January 8-9, 1981 64 
Federal Register of March 20, 1981, announcing a meeting of the RAC 
Large-Scale Review Working Group, April 22, 1981, and annoincing 
actions to be considered at a meeting of the RAC, April 23-24, 1981. ... 71 
Minutes of the Large-Scale Review VJorking Qroup meeting, April 22, 1981. . . 78 
Minutes of the RAC meeting, A^il 23-24, 1981 87 
Federal Register of Jine 10, 1981, containing the first annual update 
of" a program to assess the risks of recanbinant researcti 133 
Federal Register of July 1, 1981, pronulgating actions reconnended at 
the PAC meeting, April 23-24, 1981 141 
Federal Register of July 1, 1981, revised NIH Guidelines 149 
Federal Register of August 4, 1981, announcing actions to be considered 
at a meeting of the RAC, September 10-11, 1981, and announcing a 
meeting of the RAC Large-Scale Review Working Group, September 9, 1981 . . 176 
Minutes of the Large-Scale Review Working Group meeting, September 9, 1981 . 180 
Minutes of the RAC meeting, September 10-11, 1981 190 
Federal Register of October 30, 1981, pronulgating actions recommended 
at the meeting, September 10-11, 1981 249 
Federal Register of December 4, 1981, announcing proposed revised 
Guidelines 256 
Federal Register of December 7, 1981, announcing actions to be considered 
at a meeting of the RAC, February 8-9, 1982 315 
[v] 
